I would argue Natalie Portman in Star Wars Episode 2: Attack of the Clones, although it was more of a setback than anything else that she later recovered from. Portman played as Padme Amidala, who was Queen of the planet Naboo in Episode 1 and later became a Senator for Episode 2.
The film was panned by critics. I think that although there are some parts that could have been better, it was better than many critics said. *
14. Because Mike Nichols Shaped Generations of New York Actors, From Robert Redford to Julia Roberts
Portman: Star Wars had come out around the time of Seagull, and everyone thought I was a horrible actress. I was in the biggest-grossing movie of the decade, and no director wanted to work with me. Mike wrote a letter to Anthony Minghella and said, “Put her in Cold Mountain, I vouch for her.” And then Anthony passed me on to Tom Tykwer, who passed me on to the Wachowskis. I worked with Milos Forman a few years later. He said, “Mike saved me. He wrote a letter so that I could get asylum in the U.S.” He did that for 50 people, and it doesn’t make any one of us feel less special.
Portman’s career would later recover and she would go as far as to win an Academy Award for Best Actress in the film Black Swan, along with many other awards, but because Star Wars Episode 2 was not well received by critics, it represented a temporary setback.