The invincible Narasimhastra has been fired 3 times.
Supreme Lord Krishna fired Narasimhastra and defeated Talamegha.
Kṛṣṇa discharged Vāruṇa (pertaining to Varuṇa) and the Āgneya missile was suppressed by the Vāruṇa. Tālamegha then countered it by Vāyavya (pertaining to the Wind). Hṛṣīkeśa discharged Sārpa (pertaining to the serpent) for suppressing the Vāyavya. Nṛsiṃha (Kṛṣṇa) discharged the Nārasiṃha arrow, O son of Pāṇḍu. On seeing the Nārasiṃha, the highly powerful Tālamegha got down from the chariot quickly.
~Skanda Mahapurana, Avantya-khanda, Reva Khanda Chapter 90
Parameshwara Mahadeva fired Narasimhastra which baffled Garudastra of demon Andhakasur.
Thereat a Gāruḍa missile was sportingly discharged by the Dānava. On seeing the Gāruḍa missile the Sārpa missile disappeared. Thereupon a Nārasiṃha missile was discharged by the Lord of Devas. The Gāruḍa missile was destroyed by the Nārasiṃha missile. Thus one missile was suppressed by another missile. They did not affect either of them. O dear one, the great war became equally terrifying unto the Suras and the Asuras.
~Skanda Mahapurana, Avantya-khanda, Reva Khanda Chapter 48
Indradeva had also fired Narasimhastra which destroyed all illusions of Jambhasur.
The Dānava seized some with his trunk and thrashed them on his back. While he was destroying the armies of Suras, the slayer of Vṛtra (Indra) discharged a Narasiṃha missile that was unassailable. Thereupon, thousands of lions came out, thanks to the power of the Mantra. When the body (of the Dānava) was split and torn by them, he gave up the deceptive Maya of being an elephant.
~Skanda Mahapurana, Maheshvara Khanda, Kaumarika Khanda Chapter 21